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[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Li B., Umapathy A., Tran L.U., Donaldson P.J., Lim J.C

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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study